*When George Lopez joked about Kirstie Alley earlier in the week, he probably didn’t think it was a big deal … at the time.

However, Lopez did apologize to the actress after suggesting the “Fat Actress” actress/star, who recently lost 60 lbs., looked pig-like on the dance floor during the “Dancing with the Stars” premiere earlier this week.

“I misjudged the joke. No malice was intended and I apologize to Kirstie,” George Tweeted Thursday evening.

But it looks like malice is what Alley had in mind Friday morning when she came out blazing with a response via Twitter aimed right at the comedian’s kidney:

“@georgelopez I don’t need or want ur apology,” the actress wrote. “I want your kidney dude..on behalf of ur X and all the women uv insulted…give it back”

Whoa!

In 2005, Lopez’s then-wife, Ann, donated one of her kidneys to him after one of his deteriorated due to a genetic disorder called narrow ureters. The couple split this past September.