Serena Williams shows her frustration during her women's singles first round match against Virginie Razzano of France during day three of the French Open at Roland Garros on May 29, 2012 in Paris

*Serena Williams is out of the 2012 French Open.

The highest-seeded U.S. woman was beaten in her match against Virginie Razzano at Roland Garros, marking the first time she has ever lost in the first round of a French Open — or any Grand Slam.

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After winning the first set, 6-4, Williams, the No 5 seed, began to spiral down after failing to capture a tiebreak in the second set. Razzano won the second and third sets of the match to advance.

Williams appeared to be caught crying on camera during the changeover between the second and third sets. [Scroll down to watch.] She had jumped out to a 5-1 lead in the second set tiebreak before Razzano tied and eventually won the set.

After falling behind 5-0 in the third, Williams battled back to 5-3 but could not dig out of such a deep hole in the decisive set.

Razzano, from France, was ranked 111th in the world entering the match.