Venus Williams of USA looks on during her women's singles second round match against Agnieszka Radwanska of Poland during day four of the French Open at Roland Garros on May 30, 2012 in Paris

*With Venus Williams’ 6-2, 6-3 second-round loss to Agnieszka Radwanska on Wednesday and her sister Serena’s historic first-round loss on Tuesday, the 2012 French Open marks the earliest exit by the Williams sisters at a Grand Slam tournament.

Third-seeded Radwanska hit only six unforced errors en route to her victory.

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Williams was playing at a major tournament for the first time since last August, when she withdrew before her second-round match at the U.S. Open. It was then that she revealed she had been diagnosed with Sjogren’s syndrome, a condition that can cause fatigue and joint pain.

The good news for Venus, a seven-time Grand Slam champion, is that her first-round win virtually assures her a spot on the U.S. Olympic team, according to Sports Illustrated. She should be ranked within the top 50 when the rankings cut-off kicks in after the French Open, which is more than enough to earn her place.

She’s said in interviews that the only reason she came back so early from her autoimmune disorder was to try to qualify for the London Olympics.

As previously reported, Serena on Tuesday lost in the first round of a major tournament for the first time, falling to Virginie Razzano of France 4-6, 7-6 (5), 6-3.